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High grade astrocytic tumor

MedGen UID:
769639
•Concept ID:
C3640999
•
Neoplastic Process
Synonyms: High Grade Astrocytic Neoplasm; high grade astrocytic neoplasm; High Grade Astrocytic Tumor; high grade astrocytic tumor; High-Grade Astrocytic Neoplasm; high-grade astrocytic neoplasm; High-Grade Astrocytic Tumor; high-grade astrocytic tumor; high-grade astrocytic tumour; high-grade astrocytoma; High-grade astrocytoma
 
Monarch Initiative: MONDO:0016680
Orphanet: ORPHA251561

Definition

An astrocytic tumor exhibiting high-grade morphological characteristics. This category includes anaplastic astrocytoma, glioblastoma, and astrocytoma, IDH-mutant, grade 4. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh grade astrocytic tumor

Professional guidelines

PubMed

The management of low-grade gliomas in adults.
Morshed RA, Young JS, Hervey-Jumper SL, Berger MS
J Neurosurg Sci 2019 Aug;63(4):450-457. Epub 2019 Mar 27 doi: 10.23736/S0390-5616.19.04701-5. PMID: 30916536
Childhood brain tumors: current management, biological insights, and future directions.
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article
ESTRO-ACROP guideline "target delineation of glioblastomas".
Niyazi M, Brada M, Chalmers AJ, Combs SE, Erridge SC, Fiorentino A, Grosu AL, Lagerwaard FJ, Minniti G, Mirimanoff RO, Ricardi U, Short SC, Weber DC, Belka C
Radiother Oncol 2016 Jan;118(1):35-42. Epub 2016 Jan 6 doi: 10.1016/j.radonc.2015.12.003. PMID: 26777122

Recent clinical studies

Etiology

Long-Term Functional and Oncologic Outcomes of Glioma Surgery with and without Intraoperative Neurophysiologic Monitoring: A Retrospective Cohort Study in a Single Center.
Zhang N, Yu Z, Hameed NUF, Xu G, Song Y, Wu B, Zhang J, Qiu T, Zhuang D, Lu J, Wu J
World Neurosurg 2018 Nov;119:e94-e105. Epub 2018 Jul 17 doi: 10.1016/j.wneu.2018.07.051. PMID: 30026163
A case report of adult cerebellar high-grade glioma with H3.1 K27M mutation: a rare example of an H3 K27M mutant cerebellar tumor.
Funata N, Nobusawa S, Nakata S, Yamazaki T, Takabagake K, Koike T, Maegawa T, Yamada R, Shinoura N, Mine Y
Brain Tumor Pathol 2018 Jan;35(1):29-35. Epub 2017 Dec 20 doi: 10.1007/s10014-017-0305-9. PMID: 29264735

Diagnosis

Leptomeningeal metastases and dural spread in adult high-grade astrocytomas.
Kleinschmidt-DeMasters BK, Ormond DR
J Neuropathol Exp Neurol 2023 Feb 21;82(3):194-201. doi: 10.1093/jnen/nlac126. PMID: 36637258
Enhanced glial fibrillary acidic protein-delta expression in human astrocytic tumor.
Choi KC, Kwak SE, Kim JE, Sheen SH, Kang TC
Neurosci Lett 2009 Oct 9;463(3):182-7. Epub 2009 Jul 30 doi: 10.1016/j.neulet.2009.07.076. PMID: 19647039
Primary nodular meningeal glioma mimicking metastatic tumor of the cerebellum with diffuse infra- and supratentorial leptomeningeal spread.
Sell M, Mitrovics T, Sander BC
Clin Neuropathol 2000 May-Jun;19(3):126-30. PMID: 14606585
The combined determination of proliferative activity and cell density in the prognosis of adult patients with supratentorial high-grade astrocytic tumors.
Kiss R, Dewitte O, Decaestecker C, Camby I, Gordower L, Delbecque K, Pasteels JL, Brotchi J, Salmon I
Am J Clin Pathol 1997 Mar;107(3):321-31. doi: 10.1093/ajcp/107.3.321. PMID: 9052383

Therapy

Toxin-based targeted therapy for malignant brain tumors.
Chandramohan V, Sampson JH, Pastan I, Bigner DD
Clin Dev Immunol 2012;2012:480429. Epub 2012 Feb 9 doi: 10.1155/2012/480429. PMID: 22400035Free PMC Article

Prognosis

Toxin-based targeted therapy for malignant brain tumors.
Chandramohan V, Sampson JH, Pastan I, Bigner DD
Clin Dev Immunol 2012;2012:480429. Epub 2012 Feb 9 doi: 10.1155/2012/480429. PMID: 22400035Free PMC Article
Primary nodular meningeal glioma mimicking metastatic tumor of the cerebellum with diffuse infra- and supratentorial leptomeningeal spread.
Sell M, Mitrovics T, Sander BC
Clin Neuropathol 2000 May-Jun;19(3):126-30. PMID: 14606585
The combined determination of proliferative activity and cell density in the prognosis of adult patients with supratentorial high-grade astrocytic tumors.
Kiss R, Dewitte O, Decaestecker C, Camby I, Gordower L, Delbecque K, Pasteels JL, Brotchi J, Salmon I
Am J Clin Pathol 1997 Mar;107(3):321-31. doi: 10.1093/ajcp/107.3.321. PMID: 9052383

Clinical prediction guides

Toxin-based targeted therapy for malignant brain tumors.
Chandramohan V, Sampson JH, Pastan I, Bigner DD
Clin Dev Immunol 2012;2012:480429. Epub 2012 Feb 9 doi: 10.1155/2012/480429. PMID: 22400035Free PMC Article
Enhanced glial fibrillary acidic protein-delta expression in human astrocytic tumor.
Choi KC, Kwak SE, Kim JE, Sheen SH, Kang TC
Neurosci Lett 2009 Oct 9;463(3):182-7. Epub 2009 Jul 30 doi: 10.1016/j.neulet.2009.07.076. PMID: 19647039
The combined determination of proliferative activity and cell density in the prognosis of adult patients with supratentorial high-grade astrocytic tumors.
Kiss R, Dewitte O, Decaestecker C, Camby I, Gordower L, Delbecque K, Pasteels JL, Brotchi J, Salmon I
Am J Clin Pathol 1997 Mar;107(3):321-31. doi: 10.1093/ajcp/107.3.321. PMID: 9052383

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